Scrub Bulk Email Lists on Mac without Expensive Services or Software???

I have sourced a couple free online email lists.
One is 12.5 million business emails in the U.S
Another is 560 million random emails from around the world
I need to clean, clean, clean this list before using.
Any recommendations how to scrub the list on a Mac OSX machine without expensive online services or software?
Also, I need a good email client to connect to AWS SES, can't find a good one for Mac.
~ Thanks everyone.

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