Web App & Local app integration?

Hey guys, I'm looking in to moving a local application to a web app and I'm wondering what the options are. I'm aware that a web app by itself often has to run in a sandbox, but is there a way to integrate it with a locally installed application, so that the web app could activate the local app and get it to do things like analyze the directory structure, copy files, etc? If so, what languages/libraries should I look in to?
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