serial port open under windows

I have an application (DB/C) that opens a serial port (COM1). However, my application cannot open the com port. I start up Hyperterminal and shut it down. Then my application works. Can any one direct me on what to change or fix? I have tried a change to the Registry (VCOMMEnablePowerManagement to 00 00 00 00).
Dr. Ray Warren
Kirk Software, Inc
Wilmington, NC
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